Companies that have invested in large factories which produce d-alpha tocopherol have, understandably, been slow to promote the growing science indicating the healthful benefits of a more balanced tocopherol & tocotrienol product. The body of science clearly supports the need for all 8 isomers and the many benefits of fresh, virgin red palm oil extracted tocotrienol and tocopherol natural complexes. These companies have no tocotrienol production and are focused primarily on d-alpha tocopherol output.
On the other hand, SourceOne has built a network of exclusive alliances with leading research and product development companies around the world. We specifically sought out manufacturing partners that had responded to the newest research by developing technologies and processes to produce the most advanced products.
We’ve all heard of the latest meta-analysis studies that warn of the dangers of consuming too much vitamin E (alpha-tocopherol), or the lack of healthful benefits. However flawed these studies may be, the fact remains that the tide is turning on single isomer natural vitamin E and brand manufacturers. Marketers and consumers are looking for alternatives, namely “complete E” products that address the “full spectrum” of vitamin E isomers. Most of us think of Vitamin E as being alpha-tocopherol alone in one single isomer form. However, the fact is that in nature, there are 8 different forms or isomers of Vitamin E (alpha, beta, gamma, and delta tocopherol and the corresponding tocotrienols). The problem is, these “complete E” products are still laden with unnatural levels of alpha-tocopherol that studies have shown will actually decrease the body’s uptake of gamma tocopherol and other beneficial isomers. Unless the natural vitamin E formula contains the appropriate spectrum of isomers, in the necessary concentration of the individual isomers, the full range of heart healthy antioxidant effects will not be delivered. A “complete E” that does not provide a gamma to alpha tocopherol ratio of at least 2:1 nor has at least a 10:1 ratio of tocopherols to tocotrienols is not a completely “balanced” natural vitamin E. Most of the “complete E” products available today are not much of an improvement over the inexpensive single isomer vitamin E alpha-tocopherol products of the past.
Mother nature provides us with “appropriate spectrum” vitamin E in our food supply. As we all know, consuming enough vegetable oils, nuts, grain, and seeds to provide a healthful or therapeutic effect would add far too much fat to our diets, hence we take dietary supplements. It is no wonder that all the latest research supports natural vitamin E that contains all 8 isomers and at levels that mimic the profiles set by Mother Nature, MD.
We call this natural vitamin E isomer profile “Cardio-E.”
The key nutritional areas of focus:
Vitamin E has achieved worldwide recognition as an important dietary supplement. But not all Vitamin E products are the same. Consumers demand high-quality vitamin E products, but many have little understanding of the differences among products in terms of their bioavailability or effectiveness. SourceOne has introduced Cardio E® Naturally Balanced E Isomers as the brand that represents the next generation of appropriate spectrum natural vitamin E products.
Cardio E® Naturally Balanced E Isomers is offered using the VESIsorb® patented naturally self-assembling colloidal delivery system. The VESIsorb® delivery system has been clinically proven to increase absorption of medical, nutritional supplement, food and beverage, and cosmetic ingredients. This unique and superior innovation is protected worldwide by multiple U.S. and International granted and pending patents, and is licensed exclusively to SourceOne.
I’ve been taking vitamin E for years. Why are all these negative studies coming out?
If you’re one of the 13% of Americans who are taking vitamin E, you shouldn’t worry that it has done you any harm. The fact remains that there are far more positive studies supporting the benefits of natural vitamin E than negative. You may want to reconsider your supplement options though, regarding the isomer profile of the natural vitamin E you choose. The meta-analysis (a review of 19 clinical studies), published last November that created the media firestorm, only suggested a 4% increase in mortality in our elderly with highly compromised health conditions and consuming high doses of single isomer vitamin E. When you consider that most patients in the study were over the age of 60 with chronic health problems, you can see that the 4% finding has a very narrow bandwidth of application. Three other recent meta-analyses concluded there is no increased risk associated with vitamin E supplementation. The bottom line is there is little clinical research that indicates vitamin E (single isomer alpha-tocopherol) supplementation is harmful. When you look at all the research on alpha-tocopherol over the last twenty years, you find some positive, but also neutral or inconclusive results.
Should I stop taking vitamin E?
No, but you should make sure you are taking the “right” vitamin E. Obviously, the healthiest form of vitamin E is found in a diet rich in whole grains, nuts, seeds, and leafy green vegetables. The problem is that most Americans do not eat enough of these foods to get adequate nutrition, including vitamin E, to maintain or improve their health. Additionally, if you were to consume enough of these foods to realize a beneficial or therapeutic effect, you would also be consuming an unreasonably excessive amount of fat calories. In short, the question of vitamin E supplementation varies widely depending on each person’s needs and goals, but recent science is pointing towards supplements that mimic the nutritional profile of natural foods (higher levels of gamma & delta tocopherols and tocotrienols) as having greater benefits. A natural vitamin E with the “appropriate spectrum” of all 8 isomers, in the necessary concentration of the individual isomers, provides the full range of heart healthy antioxidant benefits.
What about the “complete E” or “full spectrum” products I see on the shelf? Are they any better than alpha-tocopherol?
These “complete E” or “full spectrum E” products that you see on the shelf were formulated based on the fact that there are eight total vitamin E isomers in nature and our food supply. Nature provides four tocopherol isomers (alpha, beta, gamma, and delta) and four tocotrienol isomers (alpha, beta, gamma, and delta), whereas your typical 400 IU vitamin E product on the shelf is just one isomer: alpha-tocopherol.
The problem with most of these products is they contain a large amount of alpha-tocopherol and not enough of the other 7 natural vitamin E isomers. Recent studies have suggested that alpha-tocopherol inhibits the effectiveness of both gamma-tocopherol and gamma-tocotrienol (see next question). For a “complete E” product to more closely mimic the profile found in natural foods and the latest research, alpha-tocopherol levels should only represent about 20% of the formula with 50% or more consisting of gamma-tocopherol, 10% tocotrienols, and the remainder a mix of delta and beta-tocopherols. Simply stated… decrease alpha tocopherol and significantly increase gamma and delta- tocopherols as well as tocotrienols.
How does alpha-tocopherol diminish the positive effects of gamma and delta-tocopherols?
Research has shown that supplementation of diets with alpha-tocopherol reduces serum levels of both gamma and delta-tocopherols in humans. These are the isomers we want! Conversely, supplementation of gamma-tocopherol increased both gamma and alpha-tocopherol in an animal study. All this research is pointing to the fact that we have been placing too much emphasis on alpha-tocopherol and ignoring the other tocopherols and tocotrienols. Our typical natural vitamin E supplements are out of balance with the isomer ratios that nature provides and our bodies rely on.
Is gamma-tocopherol better than alpha-tocopherol?
Actually, both gamma and alpha tocopherol each play an important role along with the other tocopherol and tocotrienol isomers in maintaining our health. Researchers have found that gamma-tocopherol is more effective than alpha-tocopherol in limiting peroxynitrite damage to lipids, in the form of liposomes and low density lipoproteins. In addition, only gamma-tocopherol has been shown to permanently trap NOx (reactive nitrogen oxides- a form of air pollution). The implication is that alpha and gamma-tocopherol play complementary roles in limiting cell damage: alpha to neutralize oxidants such as free radicals, and gamma to trap nitrogen oxides (NOx). The key is to look for supplements that contain higher levels of gamma tocopherol as well as to tocotrienols.