Polymethoxylated flavones—flavonoid compounds derived from the peels of oranges, tangerines, and other citrus fruits—are highly methoxylated and contain biologically active molecules with unique metabolic properties.
Two of the most-researched polymethoxylated flavones are nobiletin and tangeretin.
Limonoids are powerful phytochemicals abundant in citrus fruit.
Eriocitrin (eriodictyol 7-O-β-rutinoside), a flavonoid glycoside, is the key flavonoid in lemon fruit (citrus limon). Eriocitrin is very elusive and is the most soluble of all flavonoids.
Research regarding the health benefits of limonoids is exciting. They are extremely bio-active highly oxygenated phytochemical compounds. They are similar to citrus polymethoxylated flavones ( PMF) , support heart health naturally, and are synergistic in combination with them.
With over 80 years of analytical experience and expertise, Ingredients By Nature (which evolved from Syntech Corporation and Test Laboratories Inc. dba Brewster Foods) is a pioneer in citrus bioflavonoids and extracts. With a new showcase facility and on-site state-of-the-art laboratory, Ingredients By Nature ( IBN) continues to extend its lead as the premier supplier of citrus PMFs, limonoids and eriocitrin; a rapidly growing category with an ever-increasing list of health and wellness benefits attributed to these powerful natural citrus phytochemicals.
|Important Features||Original Citrus PMF & Tocotrienol Formula||Cholesstrinol HPe Significant Advantages|
|Patent Protection|| U.S. Patent 6,239,114;
U.S. Patent 6,251,400;
U.S. Patent 6,987,125
| U.S. Patent 6,239,114;
U.S. Patent 6,251,400;
U.S. Patent 6,987,125;
U.S Patent 8,158,134;
U.S Serial No. 61\559,174
|Broader & deeper patent protection|
|Supports total Healthy LDL & Cholesstrinol||Yes||Yes|
|Supports Healthy C-Reactive Protein (CRP) Levels||No Studies||Yes||Improved 57%|
|Dosage||2 Capsules Per Day||1 Capsule Per Day|
|PMF-Source® Citrus Flavones||30%||65%||116%|
|PMF Nobiletin Standardized||12.4%||30%||142% concentration|
|PMF Tangeretin Standardized||14.2%||30%||111% higher concentration|
|Tocotrienol/ Tocopherol Complex||3.0%||6.0%||100% concentration|
|Eriocitrin||None||Standardized 2.5%||250% higher concentration|
U.S Patent # 6,987,125
Researchers discovered that tangeretin helps to limit apolipoprotein-B production by suppressing diacylglycerol acyltransferase, the final enzyme in the pathway of triglyceride synthesis. Triglycerides play an important role in the formation of apolipoprotein B. By limiting production of triglycerides, tangeretin effectively restricts production of apolipoprotein B.
For years it was clear our PMFs were key citrus extracts delivering a wide range of health benefits, but now with Eriocitrin, Eriodictyol, Naringenin, Hesperitin and Naringin, we have even greater benefits to offer from the Cholesstrinol family of condition specific formulas.
The bioavailability pilot study (single oral dose, double-blind, and crossover design) showed that both Nobiletin and Tangeretin in the standard PMF powder and VESIsorb® formulation were absorbed and extensively metabolized. The PMF absorption of the VESIsorb® formulation was significantly improved and faster (Tmax) compared to the standard PMF powder. Peak plasma levels (Cmax) of Nobiletin, Tangeretin and their metabolites were increased up to 800%.
Developed by Vesifact, VESIsorb® is protected worldwide by multiple U.S. and international granted and pending patents. Marc Weder, co-founder and CEO of Vesifact, commented, “These studies highlight the many advantages that this delivery system represents. We have been able to broaden the applications for certain bio-active ingredients like CoQ10, QH Ubiquinol, Omega-3, citrus PMF, and palm tocotrienols from virgin red palm oil in functional foods, drink mixes and beverages. We have succeeded in this area by addressing issues such as water solubility, oxidative stability, shelf-life and uniformity of dispersion in the delivery medium.”
Weder added, “As it is widely accepted in the scientific and medical community that citrus PMFs are notoriously poorly absorbed in the body, our team of scientists viewed this new H2O-soluble PMF as a particularly intriguing challenge. This new PMF utilizing the VESIsorb® delivery system is ready for market and for formulating with other science-based heart-healthy ingredients like Omega-3, CoQ10, Virgin Red Palm Oil Tocotrienol, Resveratrol and more.”
|ITEM||DESCRIPTION||CLASS||MAJOR COMPONENTS||FOUND MAINLY IN|
|PolyMethoxylatedFlavones (PMFs)||Flavones usually occur in a glycosylated form (sugars attached to the parent “aglycone”) and may contain up to three methoxyl substituents in the ring system. Flavones also occur in citrus as aglycone; without the sugar attachments and the aglycones may contain up to 7 methoxyl substituents. The term PMF is usually applied to flavones aglycones having 4 or more methoxyl substituents.||Flavone Aglycone||Nobiletin, Tangeretin, Sinensetin, Isosinensetin,TOMSC||Sweet Orange Citrus sinensis, Bitter Orange Citrus aurantium,Tangerine Citrus reticulata|
|HO-PolyMethoxylatedFlavones (HO- PMFs)||HO-PMFs are PMFs in which one or more of the methoxyl substituents have been replaced by a hydroxyl group. HO-PMFs are also referred to as demethylated PMFs and occur naturally in citrus fruit. Some HO-PMFs may be produced via biotransformation or other synthetic pathways from PMFs. Certain monodemethylated PMFs have shown exceptional bioactivity.||Flavone Aglycone||5-demthylnobiletin,5 demethyltangeretin,
|Sweet Orange Citrus sinensis, Bitter Orange Citrus aurantium,Tangerine Citrus reticulata|
|Eriocitrin||The flavonoid, Eriocitrin, is a flavanone glycoside. It is found at higher levels in lemon than in all other species of citrus. The principal citrus flavanones are invariably combined with various sugars, especially disaccharides.||Flavanone Glycoside||N/A||Lemon Citrus limon|
|EriodictyolAglycone||Cleavage of the rutinose sugar attachment from eriocitrin produces the aglycone, eriodictyol. Eriodictyol also occurs naturally in several plants.||Flavanone Aglycone||N/A||Lemon Citrus limon|
|Naringenin||Cleavage of the sugar attachment from either naringin or narirutin, another flavanone glycoside important in citrus, produces the aglycone, naringenin. Naringenin and other flavanone aglycones occur in citrus in trace amounts only. The body converts Naringin and Narirutin into Naringenin.||Flavanone Aglycone||N/A||Grapefruit Citrus paradisi, Sweet Orange Citrus Citrussinensis|
|Limonoids||Limonoids are oxygenated triterpene derivatives abundant in citrus fruits. Limonin is the predominant limonoid in all major citrus species and is the bitter principle found in the navel orange. Limonoids are found throughout citrus fruit tissues but are especially concentrated in the seeds. Limonoids also occur in citrus as non-bitter glycosides.||Citrus Extract||jor Limonoids:Limonin, Nomilin||Citrus Fruits|
|Other Bioflavonoids: Diosmin, Naringin, Hesperidin, Hesperitin, Neohesperidin|