– Dr. Zheng-Xian Liu
The worldwide introduction of CoQsource® – featuring VESIsorb® delivery system – for oral application represents a unique and patented solution to improve the absorption of poorly water soluble bio-actives, especially CoQ10.
Every cell in the body requires CoQ10 for energy production and antioxidant protstection, and to enable all cells, tissues and organs to function normally. It is found in every cell of the body and is important for many organs and functions in the body that require a lot of energy, including the heart, brain and immune system, so it is not surprising that CoQ10 is highly concentrated in major organs – the heart, brain, liver and kidneys.
This is particularly important to overall health and energy levels, as our body’s natural levels of CoQ10 decrease with age. CoQ10 supports our body’s ability to help manage stress, which tend to manifest with increasing frequency as we get older. The importance of improving uptake, absorption, and bioavailability is also quite evident.
Further, the need for supplementing with CoQ10 has never been greater, especially with the dramatic increase in the number of people taking statin drugs. It is well established that statins lower cholesterol by blocking cholesterol synthesis, but statins also block the body’s natural CoQ10 production and deplete CoQ10 stored in the body.
The patented VESIsorb® self-assembling colloidal droplet delivery system is technologically advanced and more scientifically sophisticated than other so called “enhanced absorption systems.” The superiority of the delivery system has consistently been demonstrated in well-designed pilot and peer reviewed published pharmacokinetic absorption and bioavailability studies. The colloidal droplet system is customized to each active like CoQ10 or combinations of actives like CoQ10 plus Omegachoice concentrated EPA/DHA Omega-3 Fish oils. Successful VESIsorb® formulations are optimized for droplet conversion performance using dynamic light scattering analysis.
The goal is 100% solubilized actives, in a completely homogeneous system with mean droplet size of less than 100nm. Meeting these criteria confirms that the VESIsorb® self-assembling colloidal droplet system is working.
It is also important to understand is that the system is not only built around the unique molecular characteristics of the bio-active, but designed for optimal performance in the body. When mixed with an aqueous system, such as the GI-fluids, this unique lipid-based formulation naturally forms a self-assembling colloidal droplet delivery system containing solubilized bio-actives.
|Standard CoQ10 without VESIsorb®||CoQ10 with VESIsorb®|
|Oil drops sitting on the water||Colloidal droplet formation|
|Formula does not go into solution||100% in solution|
|Separation of ingredients||Completely homogenous colloidal solution
for optimal absorption!
Hydrophilic surfactant head
Hydrophobic surfactant tail
|A Micelle is like an aggregate of surfactant molecules dispersed in a liquid solution. Micelle in aqueous solution forms an aggregate with the hydrophilic “head” regions in contact with surrounding water (solvent), sequestering the hydrophobic tail regions in the micelle centre. In this “hydrophobic tail center” the active substance is dissolved||Liposomes with the hydrophobic bilayer and the hydrophilic inner core, enables solubilization or encapsulation of both hydrophobic and Hydrophilic drugs.||Compared to a micellar system the VESIsorb® System contains lower amounts of surfactants (which is highly desirable) and high amounts of oil (lipophilic core/center where the active substance is dissolved). Providing 100% dissolution.|
In our study “Relative bioavailability comparison of different Coenzyme Q10 formulations with novel self-assembling association colloid delivery system”; (published in Alternative Therapies in Health & Medicine 15(2) 2009, 42-49) CoQsource® was not compared to crystal CoQ10 powder. Three “bio-enhanced” formulas were selected, an oily suspension and two solubilizates.
With pressure on the supply chain of nutrition increasing every year, we realize that there is a need to effectively utilize the resources we have. Starting with nutrients and our own health seemed like a good idea to us. Using increased absorption nutrients will have a “green” impact on the environment as well; efficient use of resources, less bottles and the opportunity to balance your supplement intake as you physically have to swallow less capsules. CoQsource® supports with “LESS IS MORE”. You need less to achieve more. Fewer soft gels in your daily regimen to achieve better results!