Through SourceOne’s exclusive partnership with Vesifact, a world leader in applied technologies, drug delivery and formulation expertise we are a leading solution provider for dramatically improving absorption and bioavailability of poorly absorbed ingredients.
SourceOne utilizes patented VESIsorb® technology to assist in the absorption process and enhance the extent of dissolution. Developed by Vesifact, Baar, Switzerland, VESIsorb® is protected worldwide by more than forty U.S. and international granted and pending patents.
Leveraging innovative technologies like VESIsorb® allows SourceOne to offer branded ingredients in advanced delivery systems that deliver greater functionality and broader applications. This ensures more health-conscious consumers enjoy the many health benefits delivered by SourceOne products.
We use “natural” in describing the VESIsorb® technology because it mimics the natural physiological process of the human body. That is also why we describe the VESIsorb® formulations as “Body Ready”. It is known that poor water soluble drugs, e.g. fat soluble vitamins, are better absorbed when administered after a meal containing fat. One of the reasons for the improved absorption is the enhanced drug solubilization by bile salt mixed micelles which are formed from the digestion products of dietary triglycerides (monoglyceride and fatty acids) and bile – a nanotechnology tool developed by Mother Nature. The task of naturally formed bile salt-mixed micelles, having a size below 10 nanometers, is to transport the lipophilic molecules through the aqueous environment of the GI-tract and across the unstirred water layer to the absorptive epithelium. Individual lipid molecules, and not the micelles per se, are the species that enter the absorptive membrane. It is very important to understand that nano-size micelles are produced naturally in our bodies each and every day.
It is known that poorly water soluble drugs, e.g. fat soluble vitamins are better absorbed when administered after a meal containing fat. One of the reasons for the improved absorption is the enhanced drug solubilization by bile salt mixed micelles, formed from the digestion products of dietary triglycerides (monoglyceride and fatty acids) and bile – a tool developed by nature. The task of naturally formed bile salt-mixed micelles, having a size below 10 nm, is to transport the lipophilic molecules through the aqueous environment of the GI-tract and across the unstirred water layer to the absorptive epithelium. Individual lipid molecules, and not the micelles per se, are the species that enter the absorptive membrane. The precise manner by which lipophilic molecules cross the membrane of the enterocytes is uncertain. Until recently it was generally thought that lipids simply diffuse, individually as monomers through the lipid bilayer of the membrane into the cell. Now there is evidence that dietary fatty acids may be transported across the enterocyte membrane by specific transporter.
Once inside the enterocyte, dietary fatty acids and monoglycerides diffuse to the smooth endoplasmic reticulum, where they are resynthesized into triglycerides. Finally, the resynthesized triglycerides packaged into chylomicrons which are secreted into lymph. VESIsorb®, a lipid-based formulation that naturally self-assembles on contact with an aqueous phase into a colloidal system (so called “association colloid”) mimics this mixed micellar absorption pathway. The improvement of oral drug or natural bio-active bioavailability by this technology is broken down into three steps: Step 1: Formation of the colloidal delivery system containing the drug, Step 2: Diffusion of the colloidal system across the unstirred water layer, Step 3: Dissociation of single molecules from the colloidal system and transfer to the absorption epithelium and passive diffusion of single molecules across enterocyte membrane. Since VESIsorb® mimics the naturally occurring mixed micellar transport system of the human body it can be considered as a safe technology to improve the absorption of poorly water soluble drugs.
VESIsorb® vs. Micelles
Micelles are composed of a surfactant or surfactant mixture and the active substance to be solubilized within the center of the micelle. A micelle is like an aggregate of surfactant molecules dispersed in a liquid solution. A surfactant molecule has a hydrophilic part – called “head” – and a hydrophobic part – called “tail”. A typical micelle in an aqueous solution forms an aggregate with the hydrophilic “head” regions in contact with surrounding water (solvent), sequestering the hydrophobic tail regions in the micelle center. In this “hydrophobic tail center,” the active substance is dissolved. A “classical” micelle system does not contain oil and is a surfactant-rich system. If a micelle contains small amounts of oil, they are called “swollen” micelles.
Like micelles, VESIsorb® is an aqueous dispersion. However, the dispersed phase is composed of both surfactant AND oil and belongs, therefore, to the systemic group of micro-emulsions. The dispersed phase of VESIsorb® can be envisioned as nano-droplets composed of an oily core (triglycerides/orange oil/CoQ10) surrounded by a hydrophilic shell (polysorbate/polyglycerol esters). Compared to a micellar system, the VESIsorb® contains lower amounts of surfactant (which is highly desirable) and high amounts of oil (lipophilic core/center where the active substance is dissolved).
Micro-emulsions acting like real solutions are in a thermodynamic equilibrium and thus, cannot be accountable to the classical image of an emulsion. It is a “colloidal” solution with extremely tiny (< 100nm), highly flexible associates.
VESIsorb® vs. Liposomes
Liposomes are vesicles and composed of a phospholipid bi-layer membrane surrounding an aqueous core. Fat-soluble active substances can only be solubilized within the bi-layer membrane, thus the loading capacity is limited and lower compared to VESIsorb®.
Hydrophilic surfactant head
Hydrophobic surfactant tail
VESIsorb® formulas are BETTER ABSORBED – so they are BETTER FOR YOU.
The peer-reviewed journal, Alternative Therapies in Health and Medicine, recently published the results of a double-blind study comparing the bioavailability of patented CoQsource Bio-Enhanced CoQ10 to that of other bio-enhanced formulations. The study, entitled, “Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System,” appears in the March/April, 2009 issue, Volume 15, Number 2.
The graph shows a pharmacokinetic study (single oral dose, crossover) in humans comparing VESIsorb® CoQsource® to the same standard Coenzyme Q10 in different formulation demonstrating an increase of absorption in peak blood levels. The relative bioavialiability of a single oral dose of 120mg of CoQ10 was asserted using the AUC. The results showed 622% higher bioavialiability than the oil-based formula and 499% higher bioavialiability than the solubilizate.
A pharmacokinetic pilot study in humans comparing Ubiquinol-QH to the same Ubiquinol-QH in the VESIsorb® delivery system demonstrated an increase of 696% in peak blood levels of Ubiquinol. The relative bioavailability calculated using the area under the curve was also increased by485%.
Omega Choice® concentrated Co2 critical extraction EPA:
A pharmacokinetic pilot study in humans comparing OmegaChoice™ 90 Concentrated Omega-3 EPA to the same OmegaChoice™ 90 in the VESIsorb® delivery system demonstrated an increase of 567% in peak blood levels of EPA. The relative bioavailability calculated using the area under the curve was also increased by 487%.
VESIsorb® has been successfully applied to other natural science based ingredients:
We have successfully developed VESIsorb® formulations with many other natural bio-active ingredients including CoQ10 in both the Ubiquinone and KanekaQH™ Ubiquinol forms, Concentrated Omega-3 EPA/DHA Fish Oils, Vitamin D, Resveratrol, Palm Tocotrienols, Gamma Tocopherols, Citrus Polymethoxylated Flavones (PMFs), and more. PMFs are notoriously poorly absorbed, and we have dramatically improved their absorption, solubility and application in food and beverages.